The Impact of Chinese Herbal Medicine on Survival in Lung Cancer Patients Receiving Targeted Therapy  
Author Wei Shan Chang

 
Co-Author(s) Kai-Yuan Hsiao;  Shi-Chen Ou; Hao-Ren Yao; Der-Chen Chang; Ben-Chang Shia

 
Abstract There is limited large-scale cohort evidence regarding the benefits of CHM on lung cancer survival, particularly in patients receiving targeted therapies. This nationwide population-based study aimed to investigate the prognostic impact of CHM on survival outcomes in lung cancer patients undergoing standard treatments, including targeted therapies. Lung cancer patients diagnosed between 2015 and 2020 were identified, and those receiving targeted therapies were further analyzed. Patients were categorized into CHM and non- CHM groups based on medical records. A total of 9,343 patients were included in the final analysis, with 1,583 patients in CHM group. Data mining techniques revealed prevalent CHM utilization patterns, with Hedyotis diffusa Willd, Scutellaria barbata, and Astragalus membranaceus as the most frequently prescribed herbs. Network analysis further elucidated common herbal combinations. This study provides robust real-world evidence supporting the adjunctive role of CHM in enhancing survival outcomes for lung cancer patients receiving targeted therapy, emphasizing the importance of integrated care in clinical oncology.

 
Keywords Machine learning, Associate analysis, Chinese herbal medicine, Lung cancer
   
    Article #:  RQD2025-131
 

Proceedings of 30th ISSAT International Conference on Reliability & Quality in Design
August 6-8, 2025